Sheba shares its heart with the North


Sheba’s dedication to healthcare goes far beyond its own walls. From international medical innovations to building up the level of healthcare around Israel, Sheba is committed to saving lives wherever there is a need. Having invested in staff training and professional development, Sheba is now sharing its expertise bringing high quality healthcare to more remote areas of Israel.

As part of this commitment, Sheba entered into a partnership with Poriya Medical Center in Tiberias to help fill a pressing need for cardiac treatments. Sheba Medical Center’s senior cardiac surgeon, Dr. Erez Kachel, now has a dual role as the Head of the Cardiothoracic Surgery Unit at Poriya.

The unit provides a vital service for people living in northern Israel. Dr. Kachel explained, “People living in central Israel have 6 Cardiothoracic Surgery Units to choose from. Before we opened the unit at Poriya, someone living in the Galilee/Golan Heights regions would have to drive almost two hours to the closest cardiothoracic surgery unit.”

Now, residents of the north are able to receive the same level of service as Israelis in Israel’s center, thanks to the full range of heart treatments being performed at Poriya. The surgical success rate at Poriya stands level with that of Sheba.

As a result of the hard work and cooperation of the medical staff, the unit was successful from its inception. Dr. Kachel related, “Our journey began in November 2014, when we started building the new unit at Poriya. The plan was to perform about 70 surgeries during the first year. In reality, the rate of surgeries performed doubled. We performed 130 heart surgeries in the first 10 months!”

Although the unit at Poriya was created to meet a local need, it has also drawn patients from Central Israel and Haifa. Dr. Kachel is a leader in the area of post-cardiac surgery infections in Israel, and his expertise has attracted patients from out of the area to receive treatment.

Dr. Kachel is quick to praise the Sheba team for their contribution. “It’s important to acknowledge that without the professional and logistic support of Sheba’s staff – Professor Raanani and the medical management who dedicated themselves to the success of the program – we would not be where we are today.”

Other senior heart surgeons from Sheba who are taking part in this initiative include: Dr. Leonid Sternik, Dr. Alexander Lipey, Dr. Ami Shinfeld. Dr. Amgad Shelby and Dr. Eyal Nachum.

When needed, other staff members from Sheba are also called upon to assist with the surgical procedures, including anesthesiologists, cardiopulmonary bypass technicians and O.R nurses. Medical equipment is also loaned to Poriya as needed.

14-year-old terror victim Ayala’s speech to European Parliament

Ayala Shapira, 14, severely burned by Molotov cocktail in 2014, and her mother Ruth, speak at European Parliament pro-Judea and Samaria lobby.

reposted from Arutz Sheva, Israel National News

Ayala Shapira, ב’ בניסן תשע”ז, 3/29/2017

(Photo of Ayala taken before the terrorist attack.)


In 2014, Ayala Shapira was on her way home, in her father’s car, from a math club for intellectually gifted children.A Molotov cocktail changed her life, almost taking it. She survived and is fighting a courageous and painful, but slowly successful fight to return to normalcy. The pro-Israel lobby of the European Parliament invited Ayala and her mother to speak at their founding meeting. Here are the brave child’s words:

I am Ayala, almost fourteen. I live in El Matan in the Shomron; I like to read, write stories and draw. I would like to describe to you what it feels like to have a terrorist attack directed at you.

The truth is, at the moment it happened I didn’t really understand what was happening. I saw a ball of light coming towards us. My father quickly stepped on the brakes. The ball of light shattered my window and landed between us. It was a Molotov cocktail.  I remember that everything around us was burning. I thought I was going to die.

Afterwards, I started to act.  I tried to open my door, but wasn’t able to.  I was sure that the central door lock had melted in the heat, but then, my father opened the door from the other side.  My entire left side was on fire, but I couldn’t free my seat belt with my left hand, so I put my right hand into the flames, too. Then, I just started running. My father told me to roll around on the road to put out the fire burning me.

I want you to remember that sometimes when you think you are contributing to a peaceful cause, you’re actually contributing to murder, pain and war.

Only then did I begin to feel pain. I told my father that his shirt was also on fire and I asked him to also roll around on the road, but he didn’t stop. He wanted to save me first. 

I was hospitalized for eight months; that’s where I understood that my life was about to change drastically. Sometimes, I really miss being outside and feeling the sun and doing all the things I want to do.  The hardest thing is when people look at me. I see it.  I most appreciate the people who don’t try to hide it; they look at me but ask what happened to me – why am I all covered up?

One of the terrorists who threw the Molotov cocktail at our car was a sixteen year old boy – only a few years older than me. He did it, among other reasons, to help his family economically; he knew that if he is put into prison, the Palestinian Authority would take care of them.
I want you to remember that sometimes when you think you are contributing to a peaceful cause, you’re actually contributing to murder, pain and war.

Ruth Shapira, Ayala’s young mother, speaks:

Honorable Members of Parliament, Friends of Judea and Samaria, Shomron Regional Council Chairman Yossi Dagan, Honored Guests,

I arrived here from Israel only yesterday, with my daughter Ayala, who today is almost fourteen years old. We flew more than 3 thousand kilometers – because I understand that we have the responsibility of telling you our story.

My name is Ruth, and I am the mother of six daughters, of whom Ayala is the eldest. We have lived in the Jewish Community El Matan in the Shomron for the past fifteen years.

About 2 years ago, on a Thursday evening, as I was preparing dinner for my daughters, expecting Ayala and my husband, Avner who was supposed to drive Ayala home from a class for gifted children in math in Kfar Saba, I received the phone call that changed our lives. Avner, called and told me, “We’ve been hit by a Molotov cocktail, my battery is dying, call the police” – and hung up. The first thought that passed through my mind was – have we only lost our car or G-d forbid,  lost our daughter.

That moment I stopped thinking and did everything to get them help as quickly as possible.

They didn’t wait for rescue forces on the empty road and began making it home on foot. When I saw them, Avner’s shirt was still on fire. I saw the extent of Ayala’s injuries only after she entered the house, in the light. She had horrible burns on her face and neck, on her chest, on her back and on the palms of both her hands.    My brave child walked all that way on her own before the rescue forces reached her. They entered the house.

On the way to the hospital, I realized that the situation was more serious than I had thought. Avner was hospitalized for several weeks, while Ayala was hospitalized for three weeks in intensive care, for two months in the regular ward and an additional five months in a rehabilitation ward. She suffered 30 per cent second and third degree burns on her face and her upper torso; she has undergone six operations and is expected to undergo more surgery in the future.

Today, my brave Ayala, who bears all this gracefully, must wear a pressure garment twenty four hours a day. She mustn’t be exposed to sunlight, which greatly limits her activity. She can’t go on trips, can’t get to extra-curricular activities or to her youth club on her own. She has to be driven everywhere; we must check out every school activity before she can participate in it, and she visit the hospital twice a month. She has “minor” operations on a regular basis.

While our lives changed, the lives of the terrorists’ families changed, too. They receive a salary every month from The Palestinian Authority- a reward for their terrorist attacks. This is money they receive from you, from the countries of the European Union, who transfer hundreds of millions of Euros a year to the Palestinian Authority without any supervision.

By doing so, the countries that this Parliament represents, cause the murder of israelis. All of this is enabled by the European taxpayer. Hundreds of millions of Euros are transferred annually from the European Union to the Palestinian Authority, which finances, among other groups, the Palestinian Prisoners’ Organization, schools named after terrorists who murdered children, schools calling for terror, and others.

I call out to you, members of the European Parliament, members of the Group of Friends of Judea and Samaria – to stop this kafkaesque absurdity; to stop the encouragement of killing and destroying families done by the countries this House represents.

The European representatives can no longer claim ignorance. Alongside Ayala stand, waiting for your determined reaction: The Fogel Family, a father, a mother, a baby and two children murdered in their beds on a Friday night, and whose murderers’ blood-stained hands receive a monthly financial reward for this murder – from you; the four people who were murdered while out with their friends and families in the Sarona compound in Tel Aviv – only because they were Jews; the thirty people murdered while celebrating the Passover seder night in the Park Hotel in Netanya, and thousands of other Israeli terror victims (may G-D avenge their blood) and their families. The thousands of children and families whose addition to the circle of bereavement you can prevent.

I call out to you as a mother who is trying to stop this craziness; to act immediately to stop financing the Palestinian Authority and Palestinian organizations until there is clarification and transparency for the path the money is taking, and to stop the financing of murderers. It is unthinkable that under the guise of peace and humanitarian motives of this House, hundreds of millions of Euros should be transferred to the Palestinian Authority – hundreds of millions of Euros that lead to the murdering of innocent people. It is in your hands.

Thank You

Dr. Itai Pessach, Medical Director at Intensix to Present at ISICEM 2017

Reposted from prweb

Findings show that continuous analysis of the modified SOFA score by an intelligent automated system can detect and predict significant clinical outcomes

Intensix, developer of a real-time predictive analytics platform for prediction of patient deterioration in the ICU and high acuity departments of hospitals, announced today that the company’s Medical Director, Dr. Itai Pessach will be presenting at the 37th International Symposium on Intensive Care and Emergency Medicine (ISICEM).

The poster presentation will discuss a segment of the results achieved as part of Intensix proof of concept trial at the Tel Aviv Medical Center. The presentation will focus on a computerized model used to continuously calculate a modified SOFA score to predict patient outcomes in the ICU. The analysis and model development was performed on a database of 629 septic patients with severe hemodynamic instability events admitted to a general ICU in a tertiary medical center between 2007 and 2014, and validated in 92 patients with such events admitted during 2015.

The International Symposium on Intensive Care and Emergency Medicine is organized by the departments of Intensive Care and Emergency Medicine of Erasme University Hospital, Universite Libre de Bruxelles, in association with the Belgian Society of Intensive Care and Emergency Medicine (SIZ). The meeting is one of the largest in its field, now attracting more than 6000 participants from countries world-wide. The objectives of this four day symposium are to provide participants with an up to date review of the most recent, clinically relevant, developments in research, therapy, and management of the critically ill.

Dr. Pessach is a Senior Pediatric Critical Care Physician and the Deputy Director of the Edmond and Lily Safra Children hospital, Sheba Medical Center. Dr. Pessach is an Assistant Professor of Pediatrics at the Tel-Aviv University. He is certified in allergy immunology and in pediatric critical care. He has a broad background in basic and clinical research and has published extensively in the fields of pediatric immunology and critical care. Dr. Pessach holds an MD, Ph.D. degree from the Ben-Gurion University and has trained both at Sheba medical center as well as at Children’s Hospital Boston, Harvard Medical School.

About Intensix

Intensix provides healthcare providers and administrators with high-accuracy predictive analytics that improve clinical outcomes and reduce hospital costs. The Intensix innovative analytics solution detects deterioration in real-time and delivers predictive warnings during all phases of a patient’s stay in the ICU and other high-acuity departments. Driven by innovative predictive modelling and advanced high-dimensional analytics techniques, the Intensix platform has the flexibility to manage entire patient populations as well as individualized treatment needs.

Findings from Sheba Medical Center in Pancreatic Cancer Provides New Insights

Reposted from Pharmacy Choice

Findings from Sheba Medical Center in Pancreatic Cancer Provides New Insights (Overall survival and clinical characteristics of BRCA mutation carriers with stage I/II pancreatic cancer)

By a News Reporter-Staff News Editor at Cancer Weekly Investigators publish new report on Oncology – Pancreatic Cancer. According to news reporting out of Ramat Gan, Israel, by NewsRx editors, research stated, “BRCA1/BRCA2 germ line (GL) mutation carriers with pancreatic adenocarcinoma (PDAC) may have distinct outcomes. We recently described an apparent more favourable prognosis of surgically resected BRCA-associated PDAC patients in a single-arm, uncontrolled, retrospective study.”

Our news journalists obtained a quote from the research from Sheba Medical Center, “However, the prognostic impact of GL BRCA1/2 mutations in surgically resected PDAC has not been compared with a matched control population. A larger multi-centre, case-control retrospective analysis was performed. Cases were patients with surgically resected, BRCA1/2-associated PDAC from 2004 to 2013. Controls included surgically resected PDAC cases treated during the same time period that were either BRCA non-carriers, or had no family history of breast, ovarian or pancreatic cancers. Cases and controls were matched by: age at diagnosis (within ?5-year period) and institution. Demographics, clinical history, overall survival (OS) and disease-free survival (DFS) were abstracted from patient records. Statistical comparisons were assessed using ch-and Fisher’s exact test, and median DFS/OS using Kaplan-Meier method and log-rank testing. Twenty-five patients with BRCA1-(n=4) or BRCA2 (N=21)-associated resectable PDAC were identified. Mean age was 55.7 years (range, 34-78 years), 48% (n=12) were females and 76% (n=19) were Jewish. Cases were compared (1 : 2) with 49 resectable PDAC controls, and were balanced for age, ethnicity and other relevant clinical and pathological features. BRCA-associated PDAC patients received neoadjuvant, or adjuvant platinum-based treatment more frequently than controls (7 out of 8 vs 6 out of 14) and (7 out of 21 vs 3 out of 44), respectively. No significant difference in median OS (37.06 vs 38.77 months, p=0.838) and in DFS (14.3 vs 12.0 months, p=0.303) could be demonstrated between cases and controls. A trend to increased DFS was observed among BRCA-positive cases treated with neoadjuvant/adjuvant platinum-containing regimens (n=10) compared with similarly treated controls (n=7) (39.1 vs 12.4 months, p=0.255). In this retrospective analysis, the prognosis of surgically resectable BRCA-associated PDAC is no different than that of sporadic PDAC from the same institution.”

According to the news editors, the research concluded: “The role of platinum-based adjuvant therapy in this setting requires prospective investigation.British Journal of Cancer (.”

For more information on this research see: Overall survival and clinical characteristics of BRCA mutation carriers with stage I/II pancreatic cancer. British Journal of Cancer, 2017;():. (Nature Publishing Group –; British Journal of Cancer –

Our news journalists report that additional information may be obtained by contacting T. Golan, Dept. of Oncology, Sheba Medical Center, Ramat Gan 52621, Israel. Additional authors for this research include T. Sella, E.M. O’Reilly, M.H. Katz, R. Epelbaum, D.P. Kelsen, A. Borgida, H. Maynard, H. Kindler, E. Friedmen, M. Javle and S. Gallinger (see also Oncology – Pancreatic Cancer).

Keywords for this news article include: Asia, Israel, Genetics, Oncology, Ramat Gan, Epidemiology, Gastroenterology, Pancreatic Cancer, Pancreatic Neoplasms.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC

New Neuroimmunology Study Results from Sheba Medical Center Described

Reposted from 4-traders
02/16/2017 | 01:02pm EDT

New Neuroimmunology Study Results from Sheba Medical Center Described (RAM-589.555 a new Polymerase-1 inhibitor as innovative targeted-treatment for multiple sclerosis)

By a News Reporter-Staff News Editor at Pain & Central Nervous System Week — Researchers detail new data in Nervous System Research – Neuroimmunology. According to news reporting originating from Ramat Gan, Israel, by NewsRx correspondents, research stated, “Targeting Polymerase-1 (POL1) transcription machinery is a new strategy for suppression of multiple sclerosis (MS) disease activity that is based on suppression of ribosomal biogenesis and subsequent activation of apoptosis.”

Financial support for this research came from Israel Ministry of Trade and Industry – Nofar – Industry Program (see also Nervous System Research – Neuroimmunology).

Our news editors obtained a quote from the research from Sheba Medical Center, “We developed an oral POL1 inhibiting compound RAM-589.555, that suppress ribosomal biogenesis as an innovative therapeutic approach to ameliorate MS. RAM-589.555 shows high permeability, specificity to POL1 pathway, ability to induce apoptosis and to inhibit proliferation and viability of activated lymphocytes both in vitro and in-vivo.”

According to the news editors, the research concluded: “Moreover, oral administration of RAM-589.555 blocks ribosomal RNA transcription and significantly suppresses and ameliorates experimental autoimmune encephalomyelitis (EAE).”

For more information on this research see: RAM-589.555 a new Polymerase-1 inhibitor as innovative targeted-treatment for multiple sclerosis. Journal of Neuroimmunology, 2017;302():41-48. Journal of Neuroimmunology can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier –; Journal of Neuroimmunology –

The news editors report that additional information may be obtained by contacting M. Gurevich, Sheba Med Center, Multiple Sclerosis Center, IL-52621 Ramat Gan, Israel. Additional authors for this research include R. Zilkha-Falb, R. Mashiach and M. Gurevich.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC

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